What is L-Methylfolate?
The natural form of vitamin B-9 is folate, which is present in many foods such as; leafy green vegetables, fruits, etc. Folate is a potential chemical; its deficiency can lead to many diseases. Therefore, its synthetic form is present in various forms: folic acid, 5-MTHF, l-methylfolate, and tetrahydrofolate.
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However, l-methylfolate is most significant because all other forms are eventually converted into l-methylfolate in your body. Folates’ active form is l-methylfolate which is found in the human body. The bioavailability of l-methylfolate is greater than folic acid.
L-methylfolate is known as a medicinal food and almost a safe chemical. It participates in the treatment of many disorders. Let’s together explore its benefits in your body.
What is it good for?
L-methylfolate is good for you in many ways. You may think that it hardly regulates 2-3 mechanisms; but, it participates in uncountable mechanisms of your body. We share some benefits of l-methylfolate in your body.
L-Methylfolate and depression:
Fortunately, l-methylfolate can cross the blood-brain barrier and have excess to your brain. It acts as an augmenting agent for depression patients. Many depressive patients do not respond to antidepressant drugs; doctors prescribed l-methylfolate to treat depression. The psychiatrist prescribed l-methylfolate along with selective serotonin reuptake inhibitors (SSRIs) resistance and serotonin-norepinephrine reuptake inhibitors (SNRIs), which are two main classes of antidepressant drugs.
L-methylfolate is not an antidepressant drug; It induces the production of happiness chemicals such as; serotonin, dopamine, and norepinephrine. It boosts the efficacy of SSRIs and SNRIs resistance drugs.
L-Methylfolate and pregnancy:
We know that folate is vital during pregnancy because it is involved in fetus cells’ production and growth. Thus, mothers should take folic acid 400 mcg or above per day. If the mother experiences stress and living in anxiety conditions during pregnancy, can directly impacts the baby. Hence, l-methylfolate with antidepressant drugs is used to treat depression in pregnant women.
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Simply, you can say that the l-methylfolate deficiency can cause depressive disorders.
L-Methylfolate and Methylation:
Methylation is an activation process of your body; many chemicals activate through this process. L-Methylfolate supplies the methyl group added to various chemicals and activate them to work in your body.
L-Methylfolate and Homocysteine:
L-methylfolate involves during the metabolic pathways of homocysteine. It helps to convert homocysteine into methionine and cysteine. If it does not break down, its level increases in your blood and causes cardiovascular disease.
L-Methylfolate and Megaloblastic Anemia:
L-methylfolate is used to treat megaloblastic anemia. The scarcity of red blood cells (RBC) causes megaloblastic anemia in your body. L-methylfolate triggers the production of new red blood cells, increases the RBC level and treats anemia.
However, besides these roles, l-methylfolate plays a remarkable role in other various body cycles.
L-methylfolate dosage:
It is available in tablets form of 7.5 mg and 15mg. You consult with your doctor before using l-methylfolate.
- For depression and megaloblastic anemia, use 5-15 mg l-methylfolate with antidepressant drugs per day.
If you are suffering from other diseases and use medicines, please talk to your doctor before intaking l-methylfolate. It may interact with other medications.
Why is l-methylfolate good for MTHFR gene mutation patients than folic acid?
If the MTHFR gene is muted, your body cannot synthesize the Methylenetetrahydrofolate Reductase enzyme. This enzyme is responsible for converting folate and folic acid into active form l-methylfolate. If you are taking folic acid, it has no benefits for you because your body cannot transform it into l-methylfolate. The patients associated with MTHFR gene mutation should intake l-methylfolate.
Conclusion:
L-methylfolate is a medicinal supplement used to treat many major disorders. No doubt, it’s a safe chemical with fewer side effects. It can penetrate the brain, which induces the synthesis of mood-regulating chemicals. L-methylfolate is a blessing for patients with MTHFR gene mutations.
References:
https://www.psychiatrictimes.com/view/l-methylfolate-augmenting-agent-may-contribute-agitation-and-mania
